Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury
This study addresses an important question in liver biology: how zonal hepatocytes balance survival and proliferation following injury; using spatial transcriptomics, mechanistic perturbations, and ...
As a global staple crop, rice production is seriously threatened by biotic and abiotic stresses. OsMYB, which is a core transcriptional regulator in plants, mediates key processes, including secondary ...
Background Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational ...
The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The CGG triplet repeat binding protein 1 ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Locusts, as devastating pests, can reversibly ...
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
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Transcription factors are a class of proteins that interact with DNA to regulate gene expression. They’re also implicated in many cancers. For years, scientists have considered transcription factors ...
To function effectively as an integrated system, the transcriptional and post-transcriptional machineries must communicate through mechanisms that are still poorly understood. Here, we focus on the ...
Our world today is populated by multicellular organisms, from big trees to climate-wrecking humans. This multicellularity arose independently in plants and animals. Both animals and plants cope ...
Oligodendrocytes are the myelinating cells within the central nervous system. Many genes expressed in oligodendrocytes have been associated with brain disorders, and are controlled by complex gene ...
Reliably keeping a gene off is as important as controlling its expression level when the gene is on. Yet both tasks become challenging in the packed nuclear environment of a eukaryotic cell, where the ...
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